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. 2018 Feb 21;24(7):819–832. doi: 10.3748/wjg.v24.i7.819

Figure 4.

Figure 4

Effect of metformin on hepatic stellate cell contraction. Collagen gels were prepared in 24-well plates. A: HSCs were seeded on the collagen gel with or without PDGF-BB (10 ng/mL) and metformin (1, 5, and 10 mmol/L); B: Metformin was changed to AICAR (500 μmol/L), LY294002 (20 μmol/L), and PD98059 (10 μmol/L); C and D: After incubation for 24 h, the areas of the collagen gel were measured for analysis. (bP < 0.01 vs the control group, cP < 0.05 and dP < 0.01 vs the PDGF-BB only group). HSCs: Hepatic stellate cells.