Table 3.
Histopathological Features of 564+/+ Mice
| Age (months) | Pathology number | Sex | Spleen weight (mg) | Spleen | Lymph nodes | Lung | Kidney | Liver | Intestine/PP | Peritoneum | Thymus | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | 43010 | ND | 200 | R+; small | Negative | Degenerated | Atrophic | |||||
| 2 | 43241 | F | 240 | R+; small | His, PC+++ | R | GN+ | Inflamed | Inflamm | |||
| 2.5 | 43029 | F | Large | Abscess | MF | Atrophic | Liver thrombus | |||||
| 4 | 43143 | M | 270 | R++; plasmacytoid | Early HR; DLBCL | Lymph foci | GN+ | BD hyper | ||||
| 4 | 43145 | M | 500 | Atrophic | Blasts+++ | Lymph foci | GN+ | Abscesses | Ulcers | Atrophic | ||
| 6 | 43142 | M | 300 | R+++; FL | Lymph foci | FL focus | Atrophic | |||||
| 6.5 | 43146 | F | 190 | Atrophic; MH/EH | GN+ | MH | Atrophic | Skin ulcers and abscess | ||||
| 8.5 | 43144 | F | 410 | R+++; FL | Blasts | Lymph foci | Negative | FL foci | Atrophic | |||
| 8.5 | 42181 | F | 300 | PCL | Lymph foci | |||||||
| 9 | 43197 | F | 170 | Atrophic | Lymph foci | Negative | ||||||
| 9 | 43224 | F | 410 | MH | MH | Pneumonia | GN+ | MH+++ | Atrophic | |||
| 10 | 43179 | M | 4300 | PCL | PCL | PCL cuffs | PCL medulla | |||||
| 10 | 43182 | F | 2560 | CBL | CBL | |||||||
| 10 | 43256 | F | 2100 | Big nodule | CBL | GN+ | Lymph foci | PP CBL+++ | DLBCL | |||
| 10 | 43249 | F | 1460 | CBL/PBL | CBL/PBL | CBL/PBL | CBL | CBL | ||||
| 11 | 42183 | F | 320 | Histiocytosis | Hyperplasia | Lymph foci | Lymph foci | |||||
| 12 | 43231 | M | ND | Atypical GC | R | Lymph foci | GN+ | Lymph foci | Atrophic | |||
| 12 | 43265 | F | 550 | FL; early HA; DLBCL | Atrophic | |||||||
| 12 | 43257 | F | 2380 | ND | HR DLBCL | |||||||
| 12.5 | 43107 | F | 2050 | CBL; HS | HR DLBCL | HR DLBCL | Atrophic | |||||
| 13 | 43250 | F | 340 | R | MH | GN+ | MH | Focus HR DLBCL | Mass, medias CBL | Peritonitis | ||
| 13 | 43251 | F | 400 | CBL; apoptosis | CBL | CBL+++ | GN + CBL | |||||
| 13 | 43252 | F | ND | ND | ND | ND | ND | ND | ND | Salivary gland abscess, harderian adenoma | ||
| 13 | 43275 | F | 850 | HR DLBCL | HR DLBCL | DLBCL | GN+ | HR DLBCL | Abscess | HR DLBCL | ||
| 13 | 43279 | F | 750 | DLBCL | DLBCL | DLBCL | DLBCL | DLBCL++++ | ||||
| 13.5 | 43280 | F | 750 | DLBCL | DLBCL | Lymph foci | DLBCL | Lymph foci | Spironucleus | |||
| 14 | 43266 | F | 250 | DLBCL | Lymph foci | GN+ | PP DLBCL | Atrophic | ||||
| 14 | 43259 | F | 600 | ND | Myeloid leukocytes in vessels | GN+ | Myeloid leukocytosis | |||||
| 14 | 43273 | F | 940 | DLBCL | HR DLBCL, giant cells | Inflamed, necrosis | Atrophic | Periorbital abscess | ||||
| 14.5 | 43272 | F | 110 | Atrophic | Apoptotic | GN+ | Atrophic | Periorbital abscess |
F, female; M, male; +, minimal degree; ++, mild degree; +++, moderate degree; ++++, severe degree; BD, bile duct; CBL, centroblastic DLBCL; DLBCL, diffuse large B-cell lymphoma; EH, erythroid hyperplasia; FL, follicular B-cell lymphoma; GC, germinal center; GN, glomerulonephritis; HA, histiocyte-associated; His, histiocytosis; HR, histiocyte-rich; HS, histiocytic sarcoma; hyper, hyperplasia; Inflamm, inflammation; MF, myeloid foci; MH, myeloid hyperplasia; ND, not determined; PBL, plasmablastic lymphoma; PC, plasma cells; PCL, plasma cell leukemia; PP, Peyer's patch; R, reactive.