Figure 4.
Stereological analysis of alveolar density, alveoli number, and gas‐exchange surface area, in individual lobes of lungs from mice during normal and aberrant late lung development. The (A) alveolar density, (B) total number of alveoli in the lung, and (C) gas‐exchange surface area were determined in the lungs of mice with normal (21% O2‐exposed) and aberrant (85% O2‐exposed) late lung development. Male animals are indicated by blue symbols and female animals by red symbols. Data reflect mean ± SD (n = 6–7 animals per experimental group). (A) Statistical comparisons were made by one‐way anova with Tukey's post hoc modification. (B,C) Statistical comparisons are only illustrated for pairwise comparisons between the 21% O2‐ and 85% O2‐exposed groups, using an unpaired Student's t‐test. Additional stereology parameters are provided in Tables 1 and 2.