Table 1. Summarized clinical presentation of cases of MAC arising in CPAM in children reported before 2016.
| Study | N* | Age | Sex | Pre-Dx† | Symptoms | Loc‡ | Surgical procedure | Dx§ | Lung tumor |
|---|---|---|---|---|---|---|---|---|---|
| Ohye, 199816) | 1 | 6 yr | M | No | Pneumonia, intermittent cough, and chest pain | LLL | LLL segmentectomy+right middle lobectomy later | CPAM 1 | BAC |
| Granata, 199817) | 1 | 11 yr | M | No | Recurrent pneumonia | LLL | Left lower lobectomy | CPAM 1 | BAC |
| Papagiannopoulos, 200218) | 2 | NR | NR | No | NR∥ | NR | NR | CPAM 1 | BAC |
| NR | NR | No | NR | NR | NR | CPAM 1 | BAC | ||
| MacSweeney, 20036) | 2 | 6 mo | M | No | NR | RLL | Right lower lobectomy | CPAM 1 | BAC |
| 13 yr | M | No | NR | LLL | Left lower lobectomy | CPAM 1 | BAC | ||
| Stacher, 200419) | 4 | 3 yr | M | NR | NR | NR | NR | CPAM 1 | BAC |
| Newborn | F | NR | NR | NR | NR | CPAM 1 | BAC | ||
| 13 yr | M | NR | NR | NR | NR | CPAM 1 | AC | ||
| 3 yr | F | NR | NR | NR | NR | CPAM 1 | BAC | ||
| Ioachimescu, 200520) | 1 | 6 yr | M | No | Recurrent fever, chest pain, and cough | LLL | Left lower lobectomy | CPAM 1 | BAC, AC |
| Ramos, 200713) | 1 | 8 yr | F | No | Dry cough since age 2, recurrent broncho-pneumonia | LLL | Left lower lobectomy | CPAM 1 | BAC |
| Abecasis, 200821) | 1 | 14 yr | M | No | Asymptomatic | RLL | Right lower lobectomy | CPAM 1 detected 1 yr earlier | BAC |
| Summers, 201010) | 1 | 8 yr | F | No | Asthma since age 2, left chest pain since age 6 | LLL | Left lower lobectomy | CPAM 1 | BAC |
| Giubergia, 201222) | 1 | Newborn | F | No | Acute respiratory distress | Right lung | Right pneumonectomy | CPAM 1 | BAC |
| Ishida, 20139) | 1 | 9 yr | F | No | Fever and lung abscess. Previous lung abscess at age 6 | RLL | Right lower lobectomy | CPAM 1 | BAC |
| Li, 201423) | 1 | 2 day | M | No | Respiratory distress | RLL | Right lower lobectomy | CPAM 1 and 2 | BAC |
| Balkanli, 201424) | 1 | Newborn | F | Yes | Respiratory distress | LUL | Left upper lobectomy | CPAM 1 | BAC → AC |
| Kim, 201414) | 1 | 1 yr 11 mo | M | Yes | Asymptomatic | LUL | Left upper lobectomy | CPAM 1 | AC |
MAC, mucinous adenocarcinoma; CPAM, congenital pulmonary airway malformation; LLL, left lower lobe; BAC, bronchiolo-alveolar carcinoma; RML, right middle lobe; RLL, right lower lobe; AC, adenocarcinoma; LUL, left upper lobe.
*N, number of patients. †Pre-Dx, prenatal diagnosis. ‡Loc, location of pulmonary malformation. §Dx, type of pulmonary malformation. ∥NR, insufficient information.