Fig. 3.

A) Receiver operating characteristic (ROC) curve of the multivariate Cox proportional hazard model based on dataset population. Area under the curve (AUC) is 0.75 (CI = 0.67-0.83). B) Internal validation: calibration plot estimating the observed probabilities of the outcome Maculopathy = TRUE (y-axis) in relation to the predicted probabilities (x-axis). Dotted line indicates perfect prediction. Round black dots show subjects grouped by similar probabilities (quantiles) of dataset population, the brackets show 95% CI of the prediction, and the points are joint by straight lines. No statistically significant difference was observed between actual and predicted maculopathy (p = 1)