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. 2017 Nov 23;118(3):378–387. doi: 10.1038/bjc.2017.422

Figure 2.

Figure 2

Disease-specific survival (DSS) according to the staining index (SI) criteria and apical HER2 loss. Low HER2 represents SI 0–6 and High HER2 represents SI 9. Kaplan–Meier curves representing endometrial carcinoma DSS according to HER2 protein levels assessed by the SI criteria (A). DSS according to HER2 assessed by the SI criteria for patients with HercepTest Score 3+ tumours (B). Tumours with complete HER2 membrane staining (C) and HER2 apical loss (D) in endometrioid (EEC; left) and serous (S; right) tumours. DSS according to the HercepTest after re-evaluation of HER2 scoring considering apical loss in four groups (E). DSS according to the original FDA HercepTest criteria in four groups (F).