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. 2017 Jun 27;32(2):332–342. doi: 10.1038/leu.2017.177

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Mutation signature analysis. (a) Three mutation signatures identified across 46 patients using non-negative matrix factorisation (NMF). (b) Correlations between signatures identified in 46 patients and the corresponding age, or proportion of mutated canonical AID or APOBEC sites per subtracted somatic sample. Blue lines=regression lines, and P-values from the glm. (c) Proportions of mutation signatures from Alexandrov (2013),29,43 where Sig.1B corresponds to Alexandrov Signature 1B, and so on, and signatures found across 46 patients.