Table 1.
Anticoagulation, APTT, urea reduction rate and blood volume in mean for each treatment mode. Mean ± SD and range (when appropriate) is given for added unfractionated heparin (heparin), activated partial thromboplastin time (APTT), urea reduction rate (URR) and blood volume dialysed per haemodialysis session
| Heparin n = 20 |
HA n = 21 |
HAC n = 19 |
Evodial® n = 19 |
SHD
n = 23 |
|
|---|---|---|---|---|---|
| Added heparin*, Units (range) | 852 ± 907 (0–2600) |
474 ± 713 (0–2500) |
274 ± 611 (0–2000) |
184 ± 299 (0–1000) |
4413 ± 1838
**
(2500–9000 * ) |
| Treatments without heparin, % | 48 | 52 | 52 | 64 | 0 |
| APTT 30′, sec (range) | 37 ± 16 a)
(25–96) |
34 ± 7 b)
(26–50) |
34 ± 8 a)
(27–56) |
31 ± 4 a)
(25–40) |
98 ± 39
(49–181) |
| APTT 180′sec (range) | 38 ± 21 (25–110) |
30 ± 3 c)
(23–34) |
30 ± 4 b)
(24–44) |
29 ± 3 b)
(24–35) |
48 ± 15
(30–85) |
| URR 30′, % | 25 ± 8 e) | 28 ± 6e,f) | 26 ± 9 | 22 ± 7 c) | 27 ± 6 |
| URR 180′, % | 57 ± 30e,f) | 61 ± 9 e) | 61 ± 8a,d,e) | 55 ± 15 c) | 63 ± 7 |
| Blood volumeprocessed, L (range) | 56.9 ± 21.3 (1.5–92.9) |
61.5 ± 12 (42.8–82.2) |
61.9 ± 18 (0–80.5) |
60.9 ± 12 (0–83) |
65.1 ± 11.7
(43–83.3) |
| Treatment duration, min (range) | 197 ± 64 (5–249) |
217 ± 21 (165–240) |
209 ± 54 (179–240) |
206 ± 55 (10–240) |
220 ± 23
(177–241) |
Units used until 180 min of dialysis. If stop appeared due to clotting, the dose heparin used was calculated as the even upper 100-Unit value of 20 × body weight
*Unfractionated heparin in all modes except SHD, **Tinzaparin
HA heparin-albumin, HAC heparin-albumin and citrate, SHD standard haemodialysis
a) p < 0.05 vs. SHD
b) p < 0.01 vs. SHD
c) p = 0.001 vs. SHD
d) p < 0.05 vs. Evodial®
e) p < 0.01 vs. Evodial®
f) p < 0.05 vs. HAC