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. 2017 Oct 23;37(6):697–709. doi: 10.1038/onc.2017.358

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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FAM49B expression in PDAC and its correlation with LN invasion (a) Representative sections of tumors showing positive and negative immunostaining for FAM49B. The scale bars represent a 100-μm inset, × 600 magnification. (b) LN metastasis percentage in PDAC patients with positive and negative FAM49B expression. (c) Comparison of the proportions of a total of 89 patients with positive (n=23) and negative (n=65) FAM49B expression and positive lymph nodes. The results were analyzed with the Mann–Whitney U-test. (d) Representative sections of different grading derived from the PDAC GEM mouse models (LSL-KrasG12D/+, Pdx-1-Cre (KC); LSL- KrasG12D/+, LSL-Tp53R172H/+ and Pdx-1-Cre (KPC)) at different ages 3, 6, 9 and 12 months (n=8/age). The scale bar represents 100-μm.