Table 1.
Mechanisms of memory forgetting: behavioral effects of inhibition or facilitation of molecular events involved in active forgetting.
| Animal target | Learning task | Memory stage | Inhibition | Facilitation |
|---|---|---|---|---|
| Drosophila Rac1 | Olfactory aversive conditioning | Early | Persistence | Forgetting |
| Drosophila Dopamine neurons | Olfactory aversive or appetitive conditioning | Early (3 h) | Persistence of early memory (6 h) | Forgetting |
| Drosophila Dopamine receptor DAMB | Olfactory aversive conditioning | Early (3 h) | Persistence (Up to 24 h) | ND |
| Drosophila scribble | Olfactory aversive conditioning | Early | Persistence (up to 24 h) | ND |
| Drosophila Cdc42 | Olfactory aversive | Intermediate | Persistence of Anesthesia-resistant-memory | Forgetting |
| Mouse Rac1 | Object recognition | LTM (24 h) | Increased duration (up to 5 days) | Forgetting |
| Rat Dopamine receptor (D5?) | Conditioned place preference (appetitive) | LTM | Persistence of LTM (up to 14 days) | Forgetting |
| Mouse Adult neurogenesis | Aversive and appetitive tasks | LTM | Persistence of LTM (up to 6 weeks) | Forgetting |