Figure 5.

Genetic deletion of Alox15 modestly attenuates chronic-binge–ethanol (EtOH)-induced liver injury with no effect of hepatic steatosis. A and B: Liver levels of 9- and 13-HODEs. C and D: Liver 15- and 12-HETE levels. E: Representative images of hepatic hematoxylin and eosin (H&E) staining. F: Biochemical assessment of liver triglycerides (TGs). G: Serum ALT levels (data are from two independent experiments). Data are expressed as means ± SEM. Each experiment is a representative or the average of 5–8 mice per group. ^∗P < 0.05. Original magnification, ×400 (E). WT, wild-type. HETE, hydroxyeicosatetraenoic acid; HODE, hydroxyoctadecadienoic acid.