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. 2018 Feb 6;9:51. doi: 10.3389/fphar.2018.00051

Figure 4.

Figure 4

Effect of pistachios on cytokines co-localization with inflammatory cell marker. Positive co-staining of TNF-α (C) and IL-1β (D) with CD45 increased in STZ-I/R rats during the ischemia reperfusion injury. NP reduced the number of positive cells (E,F see densitometric analysis I,L). RP provided a minor effect on TNF-α (G see densitometric analysis I) and IL-1β (H see densitometric analysis L) co-localization with CD45. No positive cells were detected in sham treated animals (A,B). The pictures are indicative of at least three experiments performed on different experimental days. Images are representative of all the mice in every group. A resolution of 8 bits was used to digitalize all images into an rank of 2048 x 2048 pixels. Data are means ± S.E.M. of 10 rats for each group. *P < 0.05 vs. sham, °P < 0.05 vs. ischemia-reperfusion. The yellow arrow indicates positive cells where is detected the co-localization.