Table 2.
Potential Precursors of Type I and Type II Tumors
| Tumor | Precursor site of origin | Potential precursor lesion | Immediate precursor |
|---|---|---|---|
| Invasive LGSC | Fallopian tube | Papillary tubal hyperplasia | Atypical proliferative tumor/noninvasive LGSC |
| Endometrioid | Endometrium | Endometriosis | Atypical proliferative tumor |
| Clear cell | Endometrium | Endometriosis | Atypical proliferative tumor/noninvasive |
| Seromucinous | Endometrium | Endometriosis | Atypical proliferative tumor/noninvasive |
| Mucinous | Tuboperitoneal junction | Transitional epithelium | Atypical proliferative tumor/intraepithelial carcinoma |
| Mucinous | Ovarian | Mature teratoma | Mucinous epithelium |
| Brenner | Tuboperitoneal junction | Transitional epithelium | Transitional epithelium |
| HGSC | Fallopian tube | STIC | STIC |
| Undifferentiated carcinoma | ? Fallopian tube | ? STIC | ? STIC |
| Carcinosarcoma | Fallopian tube | STIC | STIC |
| Primary peritoneal carcinoma | Fallopian tube | STIC | STIC |
?, possible; HGSC, high-grade serous carcinoma; LGSC, low-grade serous carcinoma; STIC, serous tubal intraepithelial carcinoma.