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. 2016 Apr;186(4):777–793. doi: 10.1016/j.ajpath.2015.11.024

Figure 6.

Figure 6

Dynamic expression deviations in myofibroblast progenitor and downstream transforming growth factor (TGF)-β family signaling markers in Tgfbi null lungs during alveolar septal development. A–D:In situ hybridization detection of platelet-derived growth factor receptor α (Pdgfrα) mRNA expression in developing alveoli in wild-type (A and B) and Tgfbi nulls (C and D), at postnatal day (P) 4 and P7, reveals suppression of Pdgfrα in P7 null lungs. E and G: Immunohistochemical localization of follistatin (FST) protein within P7 wild-type (E) and Tgfbi-null (G) lungs indicates excessive FST deposition in null alveoli. F and H:In situ hybridization of serpine mRNA expression in developing alveoli in P7 wild-type (F) and Tgfbi-null (H) detects up-regulation within the null lung periphery. Scale bars: 50 μm (A–F); 20 μm (G and H).