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. 2018 Feb 6;9:48. doi: 10.3389/fphys.2018.00048

Figure 9.

Figure 9

Schema of YQFM potential protective effects against hypertrophy and apoptosis by regulating miRNAs and related target genes. Colored gene icons represent genes directly mediated by YQFM in the miRNA profiling study and the key genes which were not showed up in the miRNA profiling study were added for the integrity of the figure. The blue, orange and green colors are represented for three predicted pathways: PI3K-Akt, MAPK, and Rap1 pathways, respectively. These pathways are related to Hypertrophy and Apoptosis which has been further validated on cellular model in the study. They are also related to cell survival/death, proliferation and differentiation.