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. 2018 Feb 6;10:30. doi: 10.3389/fnagi.2018.00030

Figure 2.

Figure 2

Mitochondrial dysfunction in AD: various stress insults like aging and oxidative stress disrupt client protein folding in mitochondria thereby invoking mitochondrial UPR (UPRmt). Numerous events line up; there is mitochondrial DNA (mtDNA) proliferation and deletion, misfolded Aβ overload and ROS generation. This leads to the condition of mitochondrial dysfunction and to rescue the ailing cell UPRmt is stimulated. The effect of mitochondrial dysfunction leads to development of neuropathologies associated with AD (Aliev et al., 2008, 2013; Onyango et al., 2016).