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. 2017 Sep;187(9):1984–1997. doi: 10.1016/j.ajpath.2017.05.009

Figure 5.

Figure 5

Abnormalities of paravertebral lymphatics in ADN–VEGF-C mice. Paravertebral lymphatics [brown; GFP–horseradish peroxidase (HRP)] in Prox1-GFP control and ADN–VEGF-C/Prox1-GFP littermates after 0.075 mg/mL doxycycline for 7 days. A: Thoracic wall whole mounts showing valves (arrows) in both examples, but bud-like lymphatic outgrowths (arrowheads) only in ADN–VEGF-C/Prox1-GFP mouse. Image orientation: caudal (left), rostral (right). B–D: Paravertebral lymphatics vessel diameter (B), number of bud-like outgrowths (C), and valves per millimeter vessel length (D). Each dot is the value for one paravertebral lymphatic (two vessels per mouse; three mice per group). Red lines indicate group means. ∗∗P < 0.01, ∗∗∗P < 0.001 (t-test). Scale bar = 250 μm (A).