Table 1.
Protective or deleterious effects of P2X7 receptor pharmacological inhibition or genetic deletion in infectious disease.
| Pathogen or PAMP | Pharmacological inhibitor or genetic deletion | Effect | Inflammatory mediator or immune cell involved | References |
|---|---|---|---|---|
| VIRAL INFECTIONS | ||||
| Vesicular stomatitis virus | P2X7 KO mice | Deleterious | ↓IFN-β ↑viral replication | Zhang et al., 2017 |
| Adenoviral vectors | oATP, A438079, P2X7 KO mice | Protective | ↓IL-1β, IL-6, NO, and neutrophil infiltration | Lee et al., 2012 |
| Influenza virus | P2X7 KO mice | Protective | ↓INF-γ, TNF-α, IL-6, and neutrophil infiltration | Leyva-Grado et al., 2017 |
| HIV viral proteins in brain cells | oATP, A438079, BBG, suramin | Protective | ↓ NF-κB activation, TNF-α, IL-1β, ROS, NO, MCP-1, and neuronal damage | Tewari et al., 2015; Chen et al., 2016 |
| HIV | PPADS, suramin | Protective | ↓ HIV-1 fusion CD4+ cells | Swartz et al., 2014 |
| HIV | oATP, A740003, BBG, and suramin | Protective | ↓ HIV replication in macrophages | Hazleton et al., 2012 |
| BACTERIAL INFECTIONS | ||||
| C. trachomatis | P2X7 KO mice | Deleterious | ↓IL-1β ↑ bacterial burden | Darville et al., 2007 |
| P. gingivalis | P2X7 KO mice | Deleterious | ↓IFN-γ, IL-17 | Ramos-Junior et al., 2015 |
| M. tuberculosis | ||||
| •H37RV | P2X7 KO mice | Deleterious | ↑ Treg ↑ bacterial burden |
Santos et al., 2013 |
| •Beijing 1471 or MP287/03 | P2X7 KO mice | Protective | ↓IL-1β and INF-γ ↓ bacterial burden |
Amaral et al., 2014 |
| M. bovis | P2X7 KO mice | Protective | ↓immature-like myeloid cells ↓ bacterial burden |
Bomfim et al., 2017 |
| Sepsis | ||||
| •Endotoxic shock (LPS) | P2X7 KO mice | Protective | ↑ survival ↓cytotoxicity | Yang et al., 2015 |
| •CLP model | A438079, P2X7 KO mice | Protective | ↓IL-1β, CXCL1 and CX3CL1 ↑ survival |
Wang et al., 2015a |
| •CLP model | A740003 | Protective | ↓ p-NF-κB, IL-1β, IL-6, | Wu et al., 2017a |
| •CLP model | P2X7 KO mice, BBG | Protective | ↓p-NF-κB, IL-1β, IL-6, NO, ALT, and neutrophil infiltration ↑ survival |
Santana et al., 2015 Savio et al., 2017a Savio et al., 2017b |
| •CLP model | P2X7 KO mice, oATP | Deleterious | ↑ IL-1β, IL-6, TNF-α and bacterial burden ↓ survival |
Csóka et al., 2015a |
| FUNGAL INFECTIONS | ||||
| C. albicans | KN-62 | Deleterious | ↓DC activation, PGE2 | Xu et al., 2016 |
| P. brasiliensis | P2X7 KO mice | Deleterious | ↓Th17/Th1 response ↑ fungal burden |
Feriotti et al., 2017 |
| PROTOZOA INFECTIONS | ||||
| L. amazonensis | P2X7 KO mice, A740003 | Deleterious | ↓ IL-1β and LTB4 | Chaves et al., 2014 |
| L. amazonensis | P2X7 KO mice | Deleterious | ↑IFN-γ ↓ IL-17, IL-12, and TGF-β ↑parasitic load |
Figliuolo et al., 2017a |
| T. gondii | P2X7 KO mice | Deleterious | ↓TNF-α ↓survival | Miller et al., 2011 |
| T. gondii | P2X7 KO mice | Deleterious | ↓IFN-γ, TNF-α, IL-6,CD4+ cells ↑parasitic load | Huang et al., 2017 |
| T. gondii | P2X7 KO mice | Deleterious | ↓ IL-1β, IL-12, TNF-α, and IFN-γ ↑parasitic load | Corrêa et al., 2017 |
| T. gondii | P2X7 KO mice | Deleterious | ↓ IL-1β and ROS ↑parasitic load | Moreira-Souza et al., 2017 |
| T. cruzi | P2X7 KO mice | Deleterious | ↑ mast cells | Meuser-Batista et al., 2011 |
| P. chabaudi | P2X7 KO mice | Deleterious | ↓Th1 response | Salles et al., 2017 |
| E. histolytica | oATP, KN-62 | Deleterious | ↓ IL-1β | Mortimer et al., 2015 |
| HELMINTH INFECTIONS | ||||
| H. polygyrus | BBG | Deleterious | ↓Mast cell activation ↓IL-13 | Shimokawa et al., 2017 |
| S. mansoni | P2X7 KO | Deleterious | ↑TGF-β1 ↓ survival |
Oliveira et al., 2014 |