Figure 5.

Variant calling for unmatched tumors. A: Number of variants called on: i) 209 samples for which a matched normal was unavailable, 75 samples where matched normal samples were available; and ii) variant calling was performed against the matched normal; or iii) variant calling was deliberately performed using a generic pooled normal. B: Distribution of variant frequencies for somatic mutations (red line) and additional private germline mutations (black line) identified when a generic pooled normal is used. Bars indicate mean values, whiskers indicate SEM.