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. 2018 Feb 6;9:17. doi: 10.3389/fphar.2018.00017

Figure 1.

Figure 1

25CN-NBOH induced head twitches (HTRs) (as observed for the first 20 min post-application). (A) Dose–response relation (0.5–2.5 mg/kg i.p. vs. 1.5 mg/kg s.c.) and effect of experimental habituation (0.75 vs. 1.5 mg/kg NBOH i.p. + H). (B) Effect of the 5-HT2A antagonist ketanserin [1.5 mg/kg NBOH + 0.75 mg/kg K (30 min pre-treatment), i.p.] and the 5-HT2C antagonist SB-242084 [1.5 vs. 3.0 mg/kg NBOH + 0.5 mg/kg SB (30 min pre-treatment), i.p.], respectively. Mean + SEM; n = 4–6 per group. Kruskal-Wallis, post-hoc comparison to saline, *p ≤ 05 and **p ≤ 01; or to agonist w/o habituation and w/o antagonist pre-treatment, respectively, #p ≤.05.