Figure 5.

Subchronic tolerance to 25CN-NBOH induced head twitches (HTRs), with a total of four [1xNBOH: Once per day, 1.5 mg/kg (morning)] and seven [2xNBOH: Twice per day, 1.5 mg/kg (morning) vs. 3.0 mg/kg (evening)] i.p. injections, respectively. Head twitches were counted for the first 20 min after the morning application). Percent values indicate percent of HTRs relative to respective first day. Mean ± SEM; n = 6 per group. Repeated measures ANOVA, Bonferroni-corrected post-hoc comparison to respective first-day measurement, ^**p ≤ 01, ^***p ≤ 001 (brackets behind asterisks indicate interval(s) significance applied to).