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. 2018 Feb 6;12:29. doi: 10.3389/fncel.2018.00029

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Copyright © 2018 Moy, Khoutorsky, Asiedu, Dussor and Price.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bdnf-201 mRNA localizes to lighter polysomes in eIF4E^S209A mouse DRGs. Polysome profiling of DRG lysates from WT and eIF4E^S209A mice (A). (B,C) The relative amount of Bdnf-201 mRNA in the heavy (fraction 10–14) vs. light (fraction 5–9) polysome fractions was decreased in eIF4E^S209A mouse DRG indicating decreased Bdnf-201 mRNA translation [B, n = 3, F(13,56) = 12.5, p < 0.0001; post hoc Bonferroni’s ^∗∗∗∗p < 0.0001; C, n = 3, F(3,8) = 28.78, p = 0.0001; post hoc Bonferroni’s ^∗∗∗p = 0.0002, ^∗∗p = 0.0011 one-way ANOVA]. (D) Total Bdnf-201 mRNA amount did not differ between genotypes in samples used for polysome analysis (n = 3). (E) ActB mRNAs localize to heavy polysomes in both WT and eIF4E^S209A DRGs.