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. 2018 Feb 6;12:29. doi: 10.3389/fncel.2018.00029

FIGURE 4.

FIGURE 4

Administration of intrathecal BDNF evokes hyperalgesic priming in eIF4ES209A mice. (A) Intrathecal injection of BDNF (0.1 ng) was administered to both WT and eIF4ES209A mice. Acute mechanical hypersensitivity was blunted in eIF4ES209A mice at 3 and 24 h, but was equal in both genotypes by 48 h [n ≥ 6, F(1,60) = 18.97, p < 0.0001; post hoc Bonferroni’s ∗∗p = 0.0062, 0.0067, two-way ANOVA comparing WT vs. eIF4ES209A mice; ####p < 0.0001, two-way ANOVA compared to BL]. (B) PGE2 was injected i.pl. in WT and eIF4ES209A mice and equal hyperalgesic priming was observed in both genotypes (n ≥ 6, p > 0.05, two-way ANOVA comparing WT vs. eIF4ES209A mice; ###p = 0.0001, two-way ANOVA compared to BL).