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Proinflammatory cytokine production in tumor necrosis factor (TNF) receptor-associated periodic fever syndrome (TRAPS), and healthy control (HC) dermal fibroblast, with and without inositol-requiring enzyme 1 inhibitor 4u8C. Pre-treatment with 4u8C was followed by a stimulation with lipopolysaccharide (LPS) (10 ng/mL) in both TRAPS (n = 2) and HC (n = 6). The two-way ANOVA (p = ≤ 0.05) test was used to determine statistical significance.
