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. 2018 Feb 7;8:27. doi: 10.3389/fcimb.2018.00027

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Copyright © 2018 Eneslätt, Golovliov, Rydén and Sjöstedt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of secreted cytokines in supernatant of T cells co-cultured for 72 h with LVS-infected (A) or SCHU S4-infected (B) adherent cells from vaccinated (gray) or naïve (white) individuals. Levels of IFN-γ, MIP-1β and TNF were significantly higher in the LVS-infected cultures with cells from vaccinated individuals (^*P < 0.05), whereas no significant differences were observed for the SCHU S4-infected cultures. The levels of MCP-1 were significantly higher in cultures with cells from naïve individuals regardless of strain used (^**P < 0.01; ^***P < 0.001). Results represent data from 11 individuals of each group and each group's median is illustrated by the line through each box, with quartile one and three as the lower and upper limits of each box. The end of the vertical lines indicates maximum and minimum values, respectively.