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. 2018 Feb 7;9:62. doi: 10.3389/fphys.2018.00062

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Copyright © 2018 Liu, Zhu, Dai, Pan, Li, Wang, Yang, Yan and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ZAG on the expression of glucose-metabolism-related genes in the liver and skeletal muscle of HFD-induced obese mice. (A) The mRNA levels of Pgc1a, G6pc, Pck1, and Gys2 in mouse liver tissue. (B) The mRNA levels of Pgc1a, Glut4, Irs1 and Gys1 in mouse skeletal muscle. Data are presented as the mean ± s.e.m. SF n = 10, HFD n = 13, ZAG n = 8. Pgc1α, peroxisome proliferator-activated receptor gamma coactivator 1 alpha; G6pc, glucose-6-phosphatase, catalytic; Pck1, phosphoenolpyruvate carboxykinase 1, cytosolic; Glut4, glucose transporter type 4; Irs1, insulin receptor substrate 1; Gys1, glycogen synthase 1; Gys2, glycogen synthase 2. ^#P < 0.05 vs. SF; ^*P < 0.05 vs. HFD.