Table 4.
The effects of ZAG administration on body weight, body fat, and serum biochemical parameters in HFD-induced obese mice.
| SF (n = 10) | HFD (n = 13) | ZAG (n = 8) | |
|---|---|---|---|
| Body weight (g) | 45.0 ± 0.9 | 56.8 ± 6.9d | 48.5 ± 9.7a |
| WAT (g) | 1.62 ± 0.13 | 6.37 ± 0.68d | 2.66 ± 0.37b |
| WAT (%) | 4.70 ± 0.31 | 11.91 ± 1.01d | 5.90 ± 0.81b |
| BAT (g) | 0.18 ± 0.05 | 0.26 ± 0.15 | 0.21 ± 0.15 |
| Fasting glucose (mmol L−1) | 5.22 ± 0.75 | 8.00 ± 0.78c | 5.16 ± 0.92a |
| Fasting insulin (ng mL−1) | 0.47 ± 0.05 | 0.52 ± 0.07 | 0.63 ± 0.13 |
| HOMA-IR | 2.15 ± 0.35 | 4.42 ± 0.88 | 2.98 ± 1.19 |
| TC (mmol L−1) | 4.25 ± 0.32 | 4.90 ± 0.27 | 4.58 ± 0.36 |
| TG (mmol L−1) | 0.43 ± 0.05 | 0.40 ± 0.07 | 0.64 ± 0.12 |
| HDL-C (mmol L−1) | 2.23 ± 0.13 | 2.33 ± 0.12 | 1.91 ± 0.20 |
| LDL-C (mmol L−1) | 0.47 ± 0.08 | 0.54 ± 0.05 | 0.74 ± 0.09a |
| FFA (μmol L−1) | 1287.5 ± 109.8 | 1129.9 ± 82.7 | 1541.9 ± 98.2a |
| Lipoprotein (a) (mg L−1) | 4.10 ± 0.53 | 4.77 ± 0.47 | 5.38 ± 0.50 |
| UA (μmol L−1) | 191.90 ± 7.25 | 195.08 ± 12.85 | 333.13 ± 23.34b |
BMI, body mass index; WAT, white adipose tissue; BAT, brown adipose tissue; TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; FFA, free fatty acids; UA, uric acid; SF, standard food; HFD, high-fat diet; ZAG, zinc-α2-glycoprotein.
a
P < 0.05,
b
P < 0.01 vs. HFD group;
c
P < 0.05,
d
P < 0.01 vs. SF group.