Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 7;9:80. doi: 10.3389/fphys.2018.00080

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Koivumäki, Naumenko, Tuomainen, Takalo, Oksanen, Puttonen, Lehtonen, Kuusisto, Laakso, Koistinaho and Tavi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Analysis of an in silico database of hiPSC-CMs. (A) Ranges of variability in ion current conductances based on literature search. (B) Workflow in the database analysis. (C) 3D surface plot of APD₉₀ as a function of three ion current parameters. The variable color of the data points is not quantitative or related to the color bar scale. Instead, it is just a way to increase the contrast of the dots against the surfaces. Histograms of maximum diastolic potential (D) and AP peak potential (E) in spontaneous and paced modes. Histograms of maximal frequency of AP duration restitution (APDR) (F) and force-frequency response (FFR) (G). Maximum pacing frequency for monotonic APDR and FFR. (H) Relative parameter values in the (1) spontaneous and (2) paced modes, as well as, (3) in the monotonic APD restitution and force-frequency response subpopulations, compared to the whole database.