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. 2018 Feb 7;9:80. doi: 10.3389/fphys.2018.00080

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Copyright © 2018 Koivumäki, Naumenko, Tuomainen, Takalo, Oksanen, Puttonen, Lehtonen, Kuusisto, Laakso, Koistinaho and Tavi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of ideal hiPSC-CM and adult CM in silico. (A) The most favorable parameter combination (red line) plotted with the full parameter range of the database on background (gray bars). Action potential (B), calcium transient (C), sodium current (D), calcium current (E), sodium-calcium exchanger current (F) transient outward, rapid and slow delayed rectified potassium currents (G–I), inward rectified potassium current and sodium-potassium pump current (J), and RyR-mediated Ca²⁺ release fluxes from the sarcoplasmic reticulum (K). In the hiPSC-CM model, there are three spatially distinct release locations, as described in detail in Figure 1.