Table 1. Binding Affinity (Kd), Protein Stability Change (ΔTm), and Half-Maximum Inhibitory Concentration (IC50).
| IC50 (μM)b |
||||
|---|---|---|---|---|
| inhibitor | Kd (μM) | ΔTm (°C)a | Vero E6 | HepG2 |
| toremifene | 16 | –15 | 0.162 (0.048) | 0.026 (0.0013) |
| benztropine | 1300 | –6 | 8.07 (0) | 2.82 (0.13) |
| bepridil | 290 | –6 | 5.08 (0.38) | 3.21 (0.15) |
| paroxetine | 650 | –4 | 7.45 (0.41) | 1.38 (0.076) |
| sertraline | 950 | –3 | 3.13 (0.24) | 1.44 (0.057) |
a
ΔTm is measured at inhibitor concentration of 500 μM.
b
IC50 values and standard deviations (in parentheses) are adapted from Johansen et al.15