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. 2018 Feb 1;32(2):48–57. doi: 10.1089/apc.2017.0295

Table 1.

Demographic Characteristics, Maternal Health Measures, and Birth Characteristics of HIV-Exposed Uninfected Infants By Study Cohort

    Study, n (%)
Characteristica Total (N = 6386), n (%) WITS (N = 2464) 219C (N = 1653) SMARTT (N = 2269)
Male infant sex 3233 (51) 1253 (51) 819 (50) 1161 (51)
Race/ethnicity
 White Non-Hispanic 550 (9) 269 (11) 162 (10) 119 (5)
 Black Non-Hispanic 3534 (55) 1190 (48) 954 (58) 1390 (61)
 Hispanic (regardless of race) 2106 (33) 867 (35) 500 (30) 739 (33)
 Other/unknown 196 (3) 138 (6) 37 (2) 21 (1)
Birth year
 ≤1995 961 (15) 837 (34) 124 (8)
 1996–2000 1695 (27) 1019 (41) 633 (38) 43 (2)
 2001–2005 1688 (26) 608 (25) 893 (54) 187 (8)
 2006–2010 1139 (18) 3 (<1) 1136 (50)
 >2010 903 (14) 903 (40)
Preterm birth (<37 weeks gestation) 1108 (17) 419 (17) 242 (15) 447 (20)
Low birth weight (≤2500 g) 1119 (18) 425 (17) 285 (17) 409 (18)
Delivery by cesarean section 2862 (45) 856 (35) 732 (44) 1274 (56)
Maternal age at delivery <20 years 450 (7) 174 (7) 139 (8) 137 (6)
Maternal education< high school graduate 2249 (35) 832 (34) 651 (39) 766 (34)
Household annual income ≤$20K 3465 (54) 1839 (75) N/A 1626 (72)
Maternal substance use during pregnancy
 Tobacco 1558 (24) 913 (37) 240 (15) 405 (18)
 Alcohol 1154 (18) 841 (34) 120 (7) 193 (9)
 Illicit drugs 1270 (20) 824 (33) 250 (15) 196 (9)
Maternal health characteristics at delivery
 HIV viral load >1000 copies/mL 1504 (24) 1248 (51) N/A 256 (11)
 CD4 < 350 (cells/mm3) 1320 (21) 728 (30) N/A 592 (26)
Maternal HIV diagnosed within 2 months of delivery 127 (2) 105 (4) N/A 22 (1)
ARV regimen during pregnancy
 No ARV 595 (9) 454 (18) 96 (6) 45 (2)
 Non-HAART 1802 (28) 1021 (41) 571 (35) 210 (9)
 HAART 3774 (59) 896 (36) 924 (56) 1954 (86)
 Unknown 215 (3) 93 (4) 62 (4) 60 (3)
Time initiating ARV during pregnancy
 No ARV 595 (9) 454 (18) 96 (6) 45 (2)
 1st trimester 2417 (38) 598 (24) 596 (36) 1223 (54)
 2nd trimester 2361 (37) 873 (35) 665 (40) 823 (36)
 3rd trimester 788 (12) 436 (18) 234 (14) 118 (5)
Time initiating HAART during pregnancy
 No ARV 595 (9) 454 (18) 96 (6) 45 (2)
 Non-HAART 1802 (28) 1021 (41) 571 (35) 210 (9)
 1st trimester 1764 (28) 299 (12) 351 (21) 1114 (49)
 2nd trimester 1521 (24) 390 (16) 407 (25) 724 (32)
 3rd trimester 489 (8) 207 (8) 166 (10) 116 (5)
a

Some characteristics were not available for all participants in addition to those specifically noted as unknown or not available (N/A) above, including: preterm birth (n = 67, 1%), low birth weight (n = 82, 1%), mode of delivery (n = 256, 4%), maternal age at delivery (n = 97, 2%), maternal education (n = 173, 3%), household income (n = 345, 12% WITS, 2% SMARTT), maternal substance use during pregnancy (n = 138–144, 2%), timing of maternal HIV diagnosis (n = 1331, 7% WITS, 52% SMARTT), and timing of ARV initiation during pregnancy (n = 225, 4%). Percentages are reported among all participants in each cohort.

ARV, antiretroviral; HAART, highly active antiretroviral treatment; N/A, not available; SMARTT, Surveillance Monitoring of ART Toxicities; WITS, Women and Infant Transmission Study.