Table 4.
Bivariate Analysis of Factors Associated with an Adverse Clinical Outcome in 549 Adults with Community-Acquired Meningitis
| Baseline variables | Odds ratios (95% CI) | p |
|---|---|---|
| Male gender | 1 (0.6–1.4) | 1.0 |
| Charlson comorbidity index score ≥1 | 2.6 (1.4–4.5) | 0.001 |
| Immunosuppressed | 0.9 (0.6–1.4) | 1.0 |
| HIV infection | 1.159 (0.7–1.8) | 0.56 |
| Abnormal neurological examinationa | 8.0 (3.3–19.3) | <0.001 |
| Glasgow Coma Scale <15 | 3.5 (1.9–6.6) | <0.001 |
| Age >60 years old | 1.7 (0.8–3.5) | 0.1 |
| Serum WBC ≥12,000 cells/μL | 2.4 (1.3–4.4) | 0.006 |
| CSF protein ≥100 mg/dL | 3.9 (1.9–7.7) | <0.001 |
| CSF glucose <45 mg/dL | 3.1 (1.6–5.7) | <0.001 |
a
Abnormal neurological examination: seizures, abnormal mental status (disorientation or Glasgow Coma Scale <15), cranial nerve abnormality, focal motor deficit, or aphasia.
CI, confidence intervals; HIV, human immunodeficiency virus; WBC, white blood cell count; CSF, cerebrospinal fluid.