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Compared with the control group, acid triggered expression of ER stress markers, and 4-PBA reduced acid-induced ER stress marker levels. Knockdown of ASIC1a, which had little impact on phosphorylation of elF2α and splice of XBP1, significantly downregulated GRP78, CHOP, and Caspase12 in acid stimulus. *p < 0.05, **p < 0.01.
