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Schematic diagram highlighting ASIC1a and UPR signaling. ASIC, acid-sensing ion channel; ATF6, activating transcription factor 6; BiP, binding immunoglobulin protein; ERAD, ER-associated degradation; GRP78, glucose-regulated protein 78; IRE, inositol-requiring enzyme; PERK, protein kinase-like ER kinase; UPR, unfolded protein response.
