Table 2.
CMR Imaging Parameters: ventricular geometry, strain and LGE
| Healthy controls (n = 20) | Acute viral myocarditis (n = 20) | IIM with inflammatory myocarditis (n = 20) | P-value / age adjusted p-value | |
|---|---|---|---|---|
| LV | ||||
| - EDV index, ml/m2 | 79 ± 16 | 85 ± 12 | 78 ± 15 | 0.059 |
| - ESV index, ml/m2 | 32 ± 6 | 40 ± 8*/* | 35 ± 13 | 0.038 / 0.329 |
| - Mass index, ml/m2 | 54 ± 11 | 60 ± 10 | 55 ± 14 | 0.099 |
| - EF, % | 59 ± 4 | 53 ± 9*/* | 56 ± 10 | 0.198 |
| - GLS, % | −25 ± 3 | −24 ± 5 | −23 ± 6* | 0.235 |
| RV | ||||
| - EDV index, ml/m2 | 98 ± 21 | 99 ± 21 | 82 ± 19*/* | 0.004 / 0.036 |
| - ESV index, ml/m2 | 48 ± 14 | 50 ± 11 | 40 ± 19* | 0.010 / 0.091 |
| - EF, % | 51 ± 7 | 49 ± 4 | 53 ± 12 | 0.026 / 0.396 |
| - GLS, % | −32 ± 8 | −32 ± 7 | −33 ± 9 | 0.659 |
| LGE | ||||
| LGE positive patients | 0/20 (0%) | 20/20 (100%)* | 7/20 (35%)* | < 0.001 |
| Subepicardial LGE positive segments | 0/340 (0%) | 106/340 | 9/340 (5%)* | < 0.001 |
| Intramural LGE positive segments | 0/340 (0%) | (31%)* | 9/340 (3%)* | 0.004 |
| Subendocardial LGE positive segments | 0/340 (0%) | 0/340 (0%) | 0/340 (0%) | |
Values are mean ± SD or n / total (%). */* p < .05 compared to controls without / with age adjustment. p-values/age adjusted p-values of the direct comparison between acute viral myocarditis and IIM myocarditis are shown in the last column, using Mann-Whitney U and a multivariate regression model or Fisher’s exact test, as appropriate. Age adjusted p-values were calculated in case of significant non-adjusted p-values
IIM idiopathic inflammatory myopathy, LV left ventricular, EDV end-diastolic volume, ESV end-systolic volume, EF ejection fraction, GLS global longitudinal strain