Table 2.
Postoperative characteristicsa
| C. diff (N = 50) |
No C. diff (N = 5108) |
Overall (N = 5158) |
Hazard Ratio |
P-valueb | |
|---|---|---|---|---|---|
| Days of post-operative antibiotic prophylaxis | <.0001 | ||||
| 2 Days (24–48 hours) | 13 (26.0) | 2107 (41.2) | 2120 (41.1) | ||
| 1 Day (0–24 hours) | 11 (22.0) | 2585 (50.6) | 2596 (50.3) | 0.692 | |
| 3 Days (>48 hours) | 26 (52.0) | 416 (8.1) | 442 (8.6) | 10.033 | |
| Post-operative antibiotic prophylaxis | 0.0358 | ||||
| 1st generation cephalosporin | 19 (38.0) | 1721 (33.7) | 1740 (33.7) | 0.721 | |
| 2nd generation cephalosporin | 14 (28.0) | 2270 (44.4) | 2284 (44.3) | 0.404 | |
| Other | 17 (34.0) | 1117 (21.9) | 1134 (22.0) | ||
| ICU days | 5.0 (2.0, 8.0) | 2.0 (1.0, 3.0) | 2.0 (1.0, 3.0) | 1.069 | <.0001 |
| Ventilation duration, days | 1.0 (0.6, 2.1) | 0.6 (0.4, 1.0) | 0.6 (0.4, 1.0) | 1.087 | 0.0001 |
| Packed red blood cells, unitc | 2.0 (0.0, 8.0) | 0.0 (0.0, 3.0) | 0.0 (0.0, 3.0) | 1.225 | <.0001 |
| LOS from surgery (truncated at onset of C. diff), days | 10.0 (7.0, 17.0) | 7.0 (6.0, 10.0) | 7.0 (6.0, 10.0) | 1.069 | <.0001 |
| Non- C. difficile infectiond | 14 (28.0) | 551 (10.8) | 565 (11.0) | 3.180 | 0.0002 |
| Hyperglycemia | 37 (74.0) | 2191 (43.0) | 2228 (43.3) | 3.766 | <.0001 |
a
Continuous variables are expressed as median (IQR). Categorical variable is described as count (%).
b
Based on Cox proportional hazards model where outcome is time to C. diff infection and predictor is postoperative characteristic.
c
48.1% of patients received packed red blood cell transfusions.
d
Onset of non- C. difficile infection prior to onset of CDI for C. difficile patients.