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. 2018 Feb 12;37:24. doi: 10.1186/s13046-018-0672-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — The hypothetical model for the positive feedback loop between SMURF1 and ER alpha signaling in breast cancer cells: ER alpha signaling induces the expression of SMURF1, which subsequently stabilizes ER alpha via its HECT domain possibly by inhibiting ER alpha K48-linked polyubiqutination process