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. Author manuscript; available in PMC: 2019 Jan 24.
Published in final edited form as: Cell Syst. 2017 Dec 20;6(1):65–74.e3. doi: 10.1016/j.cels.2017.11.014

Figure 5. DeepContact Converts Evolutionary Coupling Scores to Coupling Probabilities.

Figure 5

Boxplot of precision of DeepContact with respect to the ASTRAL validation set (y axis) with DeepContact predictions binned by 0.01 probability. Mean (red) and median (blue) precision are shown for each bin; whiskers represent 5th to 95th percentiles. We trained DeepContact using a cross-entropy loss function, which effectively maximizes the ability to distinguish residue pairs less than 8 Å apart from residues more than 8 Å apart. While the probabilities are better calibrated at the ends of the distribution, those in the middle enable an objective understanding of the likely probability of contacts using the output probabilities.