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A, Geometric mean concentrations of protoporphyrin-IX (PPIX) [μg/L] vs time [h] for 2 and 20 mg/kg averaged at each time point. No PPIX was detectable for the lowest dose of 0.2 mg/kg. B, First, peak, and final values for tissue PPIX averaged for each patients with time point of measurement (averages ± SEM) for 2 and 20 mg/kg b.w. On the average, plasma PPIX peaked at 7.8 after 20 mg/kg b.w. and at 4.7 h after 2 mg/kg b.w.
