Table 3: Summary of Results From the FAME Study.

Year	Patients (n)	Participants	Endpoints	FFR cut-off value	Adenosine	Mean FFR	Treatment		Endpoints		P value
								FFR-guided group	Angio-guided group	RR with FFR guidance (95 % CI)
2009	1,005	Stable angina (or ACS if >5 days post event) Multi-vessel disease referred for PCI	Death, MI or repeat revascularisation	FFR ≤0.80	Central IV (140 μg/kg/min)	Overall cohort: 0.71 ±0.18 Ischaemic lesions: 0.60±0.14 Non-ischaemic lesions: 0.88±0.05	Angio-guided versus FFR-guided PCI (DES)	13.2	18.3	0.72 (0.54–0.96)	0.02

ACS = acute coronary syndrome; DES = drug-eluting stent; FAME = Fractional Flow Reserve versus Angiography for Multivessel Evaluation; FFR = fractional flow reserve; IV = intravenous; PCI = percutaneous coronary intervention. Source: Tonino, et al. 2009.