Table 5: Summary of Results From the FAME-2 Study.

Year	Patients (n)	Participants	Endpoints	FFR cut-off value	Adenosine	Mean FFR	Treatment	Follow-up duration	Endpoints		P value
									PCI + OMT (%)	OMT only (%)
2012	888 out Of 1,220 enrolled	Stable angina ACS (if >5 days post event), Patients considered for PCI	Death, MI, repeat revascularisation	FFR ≤0.80	Standard practice (IV (140 μg/kg/min) or IC (50 μg)	In lesions with FFR ≤0.80: 0.64±0.13 (range 0.19–0.80) FFR-guided PCI + OMT group: 0.68±0.10 OMT alone: 0.68±0.15	FFR-guided PCI (DES) + OMT versus OMT alone:	213±128 days (PCI + OMT) 214±127 days (OMT) 206±119 days (Registry group)	4.3	12.7	<0.001
2014*	As above	As above	As above	As above	As above	As above	As above	2 years	8.1 %	19.5 %	<0.001

ACS = acute coronary syndrome; DES = drug-eluting stent; FAME = Fractional Flow Reserve versus Angiography for Multivessel Evaluation; FFR = fractional flow reserve; IC = intracoronary; IV = intravenous; OMT = optimal medical therapy; PCI = percutaneous coronary intervention. Sources: De Bruyne, et al. 2012; 2014. *Primary endpoint of the FAME-2 study.