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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Biochemistry. 2016 Aug 31;55(36):5038–5048. doi: 10.1021/acs.biochem.6b00497

Table 1.

THD binding to 50% DMPS Nanodiscs in the presence of talin rod subdomains

Rod Domain Kd (µM) Fold Increase
None 0.58 ± 0.04 NA
0.5 µM R9 1.6 ± 0.1 2.8
2 µM R9 2.6 ± 0.5 4.6
32 µM R9 18 ± 10 30
0.5 µM R12-13 2.2 ± 0.2 3.8
2 µM R12-13 4.4 ± 0.5 7.5
32 µM R12-13 180 ± 40 300
0.5 µM R1R2 0.43 ± 0.01 0.7
2 µM R1R2 0.65 ± 0.06 1.1
32 µM R1R2 2.4 ± 0.2 4.2