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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Biochemistry. 2016 Aug 31;55(36):5038–5048. doi: 10.1021/acs.biochem.6b00497

Table 2.

THD F0F1 and F2F3 binding to Nanodiscs in the presence of talin rod subdomains

F0F1
Kd (µM)
F2F3
Kd (µM)

Rod Domain 50% DMPS 10% PIP2 50%DMPS 10% PIP2

None 0.45 ± 0.09 0.86 ± 0.25 1.2 ± 0.3 0.18 ± 0.01
32 µM R9 No Binding 14 ± 1 11 ± 2 0.36 ± 0.03
32 µM R12R13 No Binding 9 ± 4 10 ± 3 0.36 ± 0.03