. Author manuscript; available in PMC: 2018 Dec 7.

Published in final edited form as: ChemMedChem. 2017 Nov 16;12(23):1994–2005. doi: 10.1002/cmdc.201700592

Table 3.

Percent inhibition of mammalian targets with compound 4f^[a]

entry	target	species	percent inhibition
1	Adrenergic α_1B	rat	53
2	Dopamine D₁	human	57
3	Dopamine D₃	human	86
4	Histamine H₂	human	98
5	Leukotriene, cysteinyl CysLT₁	human	87
6	Serotonin (5-hydroxytryptamine) 5-HT_1A	human	90
7	Thyroid hormone	rat	65
8	Dopamine transporter (DAT)	human	88
9	Norepinephrine transporter (NET)	human	91

^[a]

Experiments performed in duplicate at a concentration of 10 μM; the complete profile is included in the Supporting Information.