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. Author manuscript; available in PMC: 2019 Feb 8.
Published in final edited form as: Cell. 2018 Feb 8;172(4):667–682.e15. doi: 10.1016/j.cell.2018.01.013

Figure 6. Hox gene Expression Defines LMC Organization in Leucoraja.

Figure 6

(A, B) Expression of indicated HoxA and HoxD genes at pectoral and pelvic fin levels in Leucoraja at st29. Hoxa5, Hoxa6, Hoxa7, and Hoxa9 are expressed by MNs at pectoral fin levels. Hoxd9 and Hoxd10 are expressed at pelvic fin levels. (C) Expression of Hoxa5, Hoxa7, Hoxa9, and Hoxa10 proteins in Leucoraja spinal cord at st30. HoxA proteins display collinear patterns along the rostrocaudal axis, with Hoxa5 expressed rostrally and Hoxa10 caudally. (D) Summary of Hox and Foxp1 expression patterns in the skate spinal cord. Foxp1 expression is detected as continuous column adjacent to pectoral and pelvic fins. (E) Hox protein expression at caudal pectoral/pelvic fin levels. Hoxa7 colocalizes with Foxp1 in caudal pectoral LMC neurons, while Hoxa10 colocalizes with Foxp1 in pelvic LMC neurons. (F) Hox expression patterns at pectoral fin levels. Hoxa5 is coexpressed with Foxp1 in rostral pectoral LMC neurons. Hoxa9 is coexpressed with Foxp1 in caudal pectoral LMC and colocalizes with Hoxa7. (G) Summary of Hox expression and LMC organization in skate and elephant shark, relative to the fins; and chick and mouse, relative to the forelimbs (fl) and hindlimbs (hl). See also Figure S6.