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. Author manuscript; available in PMC: 2018 Jul 31.
Published in final edited form as: Nature. 2018 Jan 31;554(7691):189–194. doi: 10.1038/nature25475

Extended Data Figure 4. Distribution and outcome of 28 HER2 exon 20 insertions.

Extended Data Figure 4

a) Percent best change and PFS plots corresponding to each type of exon 20 insertion (colour coded by synonymous amino acid change). Three cases with no change are indicated in colour-coded circles above the x-axis. b) Zoomed-in schematic of all exon 20 insertions positioned by their amino acid co-ordinates and frequencies. c) Five unique types of exon 20 insertions observed in the study with the resulting full amino acid sequences (insertion indicated in red).

PET, positron-emission tomography; PFS, progression-free survival; RECIST, Response Evaluation Criteria in Solid Tumors.