Extended Data Table 3.
PET response criteria CT, computed tomography; FDG-PET, 18F-fluorodeoxyglucose positron-emission tomography; SUVmax, maximum standardised uptake value.
| Response category | Based on sum of SUVmax from 1 to 5 target lesions. Each target lesion with initial SUVmax of >1.5 × normal liver background SUVmax |
|---|---|
| Complete metabolic response (CMR) | • Reduction of SUVmax of all
target lesions to less than normal liver background SUVmax (for
non-brain lesions) or less than normal brain background SUVmax (for
brain lesions) AND • The reduction of all other FDG-avid lesions consistent with disease to less than normal liver background SUVmax |
| Partial metabolic response (PMR) | • Sum of SUVmax of all
target lesions is decreased by ≥30% compared to
baseline sum of SUVmax of all target
lesions AND • No new lesions |
| Stable metabolic disease (SMD) | Not satisfying the criteria for CMR. PMR. PMD, or NE |
| Progressive metabolic disease (PMD) | • Sum of SUVmax, of all
target lesions is Increased by
≥30% OR • Appearance of one or more unequivocal new FDG avid lesions |
| Not evaluable (NE) | • Missing FDG-PET series or
incomplete anatomy at follow-up timepoint • A PET/CT scanner change from baseline • Variation In FDG uptake time ≥15 minutes compared to baseline • Change in reconstruction algorithm |