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. Author manuscript; available in PMC: 2019 Feb 8.
Published in final edited form as: Cell. 2018 Feb 8;172(4):731–743.e12. doi: 10.1016/j.cell.2018.01.007

Figure 1. Adipocyte-specific TBK1 deficiency increases energy expenditure and attenuates HFD-induced obesity.

Figure 1

(A) Tbk1 expression in mature adipocytes from iWAT and eWAT of 16 weeks ND or HFD-fed mice. N=3 from 9 mice. (B) Expression of Tbk1 in eWAT, iWAT and liver of Flox and ATKO mice. N=6–7. (C) Photo of dissected mice and eWAT from 16 weeks HFD-fed Flox and ATKO mice. (D) DEXA imaging of HFD-fed Flox and ATKO mice. (E) Body weight of 16 weeks HFD-fed Flox and ATKO mice. N=11–13. (F, G) Fat mass (F) or percentage of fat mass (G) in 16 weeks HFD-fed Flox and ATKO mice. N=10–11. (H) Tissues weight of HFD-fed Flox and ATKO mice. N=11–13. (I, K) OCR of 16 weeks ND (I) or HFD (K)-fed Flox and ATKO mice. N=5–6. (J, L) EE of ND (J) and HFD (L)-fed Flox and ATKO mice. N=5–6. Data are represented as mean±s.e.m. *, p<0.05. See also Figure S1.