Figure 1: What Determines Survival in Cardiogenic Shock (Left Ventricular Pump Failure) Complicating Myocardial Infarction?

In the IABP SHOCK trial[11] biomarker kinetics (CI, BNP, IL-6, APACHE II Score) were analysed within the first 96 hours for 27 survivors and 13 non-survivors after development of cardiogenic shock complicating myocardial infarction. *p=<0.05. CI (see Figure 3A) was significantly higher in survivors versus non-survivors only at 24 hours. No significant difference was seen for BNP serum levels (see Figure 3B). Values for IL-6 in serum (see Figure 3C) and for APACHE II score (see Figure 3D) were significantly higher in non-survivors in comparison with survivors throughout the time course. Respective ROC-AUC values: CI 0.771, BNP 0.502, IL-6 0.769 and APACHE II score 0.850. APACHE II Score = Acute Physiology and Chronic Health Evaluation II Score; BNP = B-type natriuretic peptide; CI = Cardiac Index; IABP SHOCK trial = Intra-aortic Balloon Pump in Cardiogenic Shock trial; IL-6 = interleukin-6; NS = non-survivors; S = survivors. Modified from Prondzinsky, et al., 2010.[11]