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. Author manuscript; available in PMC: 2018 Feb 12.
Published in final edited form as: Oncomedicine. 2017 Sep 27;2:156–167. doi: 10.7150/oncm.22477

Figure 3. A hypothetical model of IR induced ER stress and activation of the UPR.

Figure 3

IR generated reactive oxygen products react with lipids in the ER membrane. These peroxidation products activate the PERK arm of the UPR. If a strong enough ER stress response is invoked, the balance will be tipped towards apoptosis via the pro-apoptotic UPR genes.